Endocrine Abstracts

Background: Craniopharyngioma may be associated with severe morbidity. Few data exist on incidence rate (IR) and possible changes with time. The epidemiology of craniopharyngioma in Denmark has never been evaluated in detail.Objectives: To review the literature on craniopharyngioma incidence and to study the epidemiology of craniopharyngioma in Denmark during a recent 20-year period.Material and methods: Publications including data...

Objective: To evaluate the long term risk for diabetes and insulin resistance in untreated and oral contraceptive (OC) treated hirsute patients.Design: Cross sectional study.Setting: Academic tertiary-care medical centre.Patients: Of 233 Caucasian hirsute women were evaluated during 1997–2002 (baseline) and re-contacted in 2003–2004. Of 159 patients returned questionnaires and 69 attended clinical e...

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

Introduction: The osteoblast derived bone formation marker osteocalcin has been reported to decrease adipose tissue in mice. In elderly men, osteocalcin was reported to correlate inversely with fat mass.Aim: To examine the relationship between osteocalcin and regional fat depots.Method: The Odense Androgen Study is a population-based, cross-sectional study of 779 randomly selected men aged 20–29 years. Total, central, upper ex...

Background: Clinical manifestations, metabolic risk factors and diabetes risk may differ in ethnical subgroups of women with PCOS.Material and methods: A total of 1010 premenopausal women were referred with the diagnoses hirsutism or PCOS during 1997–2008. The patients underwent clinical evaluation, hormone analyses and transvaginal ultrasound (US). Oral glucose tolerance tests (OGTT) (n=500) and ACTH tests (n=434) were performed in a ...

Background: Testosterone replacement therapy in severe hypogonadism is indicated, however, the treatment of late onset hypogonadism (LOH) is debated, especially what the diagnostic criteria should be. In LOH bio-available testosterone probably gives a more accurate index of gonadal status as a diagnostic criterion as it takes SHBG into consideration. SHBG is known to increase with ageing, however, SHBG is also negatively influenced by insulin and visceral adiposity.<p clas...

Objective: PCOS patients are often characterized by insulin resistance, abdominal obesity, and low-grade inflammation. Insulin sensitizing treatment reduces the inflammatory state, but the effect on serum levels of chemokines such as migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α have not previously been evaluated in PCOS.Research design and methods: Plasma chemokine levels (M...

Background: Polycystic ovary syndrome (PCOS) could be associated with increased risk of thyroid disorders. Possible associations between TSH and cardio-metabolic risk in PCOS are debated.Methods: National Register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (OUH, N=1,146) was an embedded cohort including premenopausal women with PCOS and ...

Background: Maternal circulating cortisol and 24-h urinary free cortisol levels are up to three times higher in third trimester pregnant women compared to non-pregnant women. Maternal cortisol status could be associated with offspring sex, maternal PCOS and testosterone levels.Aims: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during 3rd trimester and to examine associations between maternal cortisol status,...

Background: Cardiorespiratory fitness is a measure for physical activity and a prognostic health indicator. However, measurement of maximal oxygen consumption (VO2max) is not possible in clinical practice.Aim: We hypothesized that body composition and testosterone levels could be used as possible determinants of VO2max in young men.Participants and design: The Odense Androgen Study, a population-based, observational study including...